The Saint and Judith Female Conventions in Ouida\u27s Held in Bondage, Strathmore, Friendship, and Moths

The following work analyzes the usage Victorian conventions of the saint and Judith figures in Ouida’s female characters in her novels Held in Bondage, Strathmore, Friendship, and Moths. These eight characters are closely related to the stereot3(^ical representations of women in society during the time Ouida wrote; however, as Ouida became more experienced and acquainted with society, her usage of the conventions altered toward realistic rather than representative women. Of the saint figures, only one female, Vere of Moths, escapes from all stereotypes. The remaining three Alma of Held in Bondage, Lucille of Strathmore, and Etoile of Friendship definitive models of virtuous womanhood. They are innocent, naive, and virginal, qualities that cast them diametrically opposite the Judith figures. These destructive women are openly sexual are and possess authority over their bodies, desires, and male lovers, making them seem powerful in a way that undercuts their femininity. However, of the four saint’s rivals, two are not wholly evil and so cannot be Judiths. Friendship\u27s Lady Joan and Moth s Jeanne de Sonnaz join Vere as Ouida’s characters who cast off repressive conventions and exhibit a trend in late Victorian fiction to move from stereotypes into reality

Responding to COVID-19 in the National Health Service in England: positive changes and learning for Knowledge for Healthcare

The article provides an overview of the response from the Health Education England library and knowledge services team to the COVID-19 pandemic. The article covers activity and initiatives that were put in place in England from March 2020 to address challenges and issues arising for library and knowledge services delivering to the National Health Service. The article reflects on the learning from the developments that have been implemented to date and considers the positive changes that have arisen in the continued delivery against five national, strategic drivers

Redemptive Portrayals of the Fallen Woman in Nineteenth Century Sensation Fiction

A study of portrayals of fallenness in the nineteenth-century sensation novels, including those written by Wilkie Collins, Mary Elizabeth Braddon, and Ouida, my dissertation locates the genre of sensation fiction front and center in allotting its heroines--bigamists, prostitutes, and the divorced--a potential for redemption unavailable to their counterparts in realist fiction. Novels became best-selling sensations because of their risqué subject material, predominantly their positioning of women in places of power, even sexual power; content--which created a sensation in the titillated reader--became synonymous with this literary form. The sensation novelists were under no compunction to reiterate overwrought clichés to argue for a correspondence between sexual purity and moral goodness like their more conventional and canonical counterparts. I argue that because sensation novels allow sexual and powerful women admission into the institution of marriage, all the while insisting their fallen heroines' moral fitness to be wives, the novels actively challenged Victorian ideals of femininity and female virtue and in doing so became a crucial component in the unmasking of nineteenth-century sexual hypocrisy.Doctor of Philosoph

Circular Networks from Distorted Metrics

Trees have long been used as a graphical representation of species relationships. However complex evolutionary events, such as genetic reassortments or hybrid speciations which occur commonly in viruses, bacteria and plants, do not fit into this elementary framework. Alternatively, various network representations have been developed. Circular networks are a natural generalization of leaf-labeled trees interpreted as split systems, that is, collections of bipartitions over leaf labels corresponding to current species. Although such networks do not explicitly model specific evolutionary events of interest, their straightforward visualization and fast reconstruction have made them a popular exploratory tool to detect network-like evolution in genetic datasets. Standard reconstruction methods for circular networks, such as Neighbor-Net, rely on an associated metric on the species set. Such a metric is first estimated from DNA sequences, which leads to a key difficulty: distantly related sequences produce statistically unreliable estimates. This is problematic for Neighbor-Net as it is based on the popular tree reconstruction method Neighbor-Joining, whose sensitivity to distance estimation errors is well established theoretically. In the tree case, more robust reconstruction methods have been developed using the notion of a distorted metric, which captures the dependence of the error in the distance through a radius of accuracy. Here we design the first circular network reconstruction method based on distorted metrics. Our method is computationally efficient. Moreover, the analysis of its radius of accuracy highlights the important role played by the maximum incompatibility, a measure of the extent to which the network differs from a tree.Comment: Submitte

Which computable biomedical knowledge objects will be regulated? Results of a UK workshop discussing the regulation of knowledge libraries and software as a medical device

Introduction: To understand when knowledge objects in a computable biomedical knowledge library are likely to be subject to regulation as a medical device in the United Kingdom. Methods: A briefing paper was circulated to a multi‐disciplinary group of 25 including regulators, lawyers and others with insights into device regulation. A 1‐day workshop was convened to discuss questions relating to our aim. A discussion paper was drafted by lead authors and circulated to other authors for their comments and contributions. Results: This article reports on those deliberations and describes how UK device regulators are likely to treat the different kinds of knowledge objects that may be stored in computable biomedical knowledge libraries. While our focus is the likely approach of UK regulators, our analogies and analysis will also be relevant to the approaches taken by regulators elsewhere. We include a table examining the implications for each of the four knowledge levels described by Boxwala in 2011 and propose an additional level. Conclusions: If a knowledge object is described as directly executable for a medical purpose to provide decision support, it will generally be in scope of UK regulation as “software as a medical device.” However, if the knowledge object consists of an algorithm, a ruleset, pseudocode or some other representation that is not directly executable and whose developers make no claim that it can be used for a medical purpose, it is not likely to be subject to regulation. We expect similar reasoning to be applied by regulators in other countries

Characterization of BRD4 during mammalian post-meiotic sperm development

During spermiogenesis, the post-meiotic phase of mammalian spermatogenesis, transcription is progressively repressed as nuclei of haploid spermatids are compacted through a dramatic chromatin reorganization involving hyper-acetylation and replacement of most histones with protamines. Although BRDT functions in transcription and histone removal in spermatids, it is unknown whether other BET family proteins play a role. Immunofluorescence of spermatogenic cells revealed BRD4 in a ring around the nuclei of spermatids containing hyper-acetylated histones. The ring lies directly adjacent to the acroplaxome, the cytoskeletal base of the acrosome, previously linked to chromatin reorganization. The BRD4 ring does not form in acrosomal mutant mice. ChIP sequencing in spermatids revealed enrichment of BRD4 and acetylated histones at the promoters of active genes. BRD4 and BRDT show distinct and synergistic binding patterns, with a pronounced enrichment of BRD4 at spermatogenesis-specific genes. Direct association of BRD4 with acetylated H4 decreases in late spermatids as acetylated histones are removed from the condensing nucleus in a wave following the progressing acrosome. These data provide evidence for a prominent transcriptional role of BRD4 and suggest a possible removal mechanism for chromatin components from the genome via the progressing acrosome as transcription is repressed in response to chromatin condensation during spermiogenesis

What kind of illness is anorexia nervosa? Revisited: some preliminary thoughts to finding a cure.

Two decades have elapsed since our publication of 'What kind of illness is anorexia nervosa?'. The question remains whether our understanding of anorexia nervosa and its treatment thereof has evolved over this time. The verdict is disappointing at best. Our current gold standard treatments remain over-valued and clinical outcomes are modest at best. Those in our field are haunted by the constant reminder that anorexia nervosa carries the highest mortality rate of any psychiatric disorder. This cannot continue and demands immediate action. In this essay, we tackle the myths that bedevil our field and explore a deeper phenotyping of anorexia nervosa. We argue that we can no longer declare agnostic views of the disorder or conceive treatments that are "brainless": it is incumbent upon us to challenge the prevailing zeitgeist and reconceptualise anorexia nervosa. Here we provide a roadmap for the future

Representing 3D Space in Working Memory: Spatial Images from Vision, Hearing, Touch, and Language

The chapter deals with a form of transient spatial representation referred to as a spatial image. Like a percept, it is externalized, scaled to the environment, and can appear in any direction about the observer. It transcends the concept of modality, as it can be based on inputs from the three spatial senses, from language, and from long-term memory. Evidence is presented that supports each of the claimed properties of the spatial image, showing that it is quite different from a visual image. Much of the evidence presented is based on spatial updating. A major concern is whether spatial images from different input modalities are functionally equivalent— that once instantiated in working memory, the spatial images from different modalities have the same functional characteristics with respect to subsequent processing, such as that involved in spatial updating. Going further, the research provides some evidence that spatial images are amodal (i.e., do not retain modality-specific features)

Measurement of the W±Z boson pair-production cross section in pp collisions at √s=13TeV with the ATLAS detector

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